MA(Oxon), MSc, PhD
I am interested in how the synapse (the junction between two neurons) is able to change its strength in response to a stimulus (plasticity). I’m especially interested in forms of plasticity where changes at one synapse can cause changes at neighbouring synapses on the same neuron. As well as being fascinating for its own sake, we hope that this work will help us to understand human memory better, which will ultimately assist the fight against diseases of memory (such as Alzheimer’s Disease).
To make progress in this work we need new imaging technologies. In collaboration with a photonics company (M Squared Life, see Aurora: Light Sheet Fluorescence Microscopy) I have been developing a custom-built light sheet microscope which we hope will enable significant new advances in our understanding of synapse plasticity.
Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APPSwe/PSEN1M146V transgenic mice.
Medawar E. et al, (2018), EBioMedicine
Fast volume-scanning light sheet microscopy reveals transient neuronal events.
Haslehurst P. et al, (2018), Biomed Opt Express, 9, 2154 - 2167
Rapid imaging of mammalian brain slices with a compact light sheet fluorescent microscope
Yang Z. et al, (2017), Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 10051
An inverted light sheet microscope optimized for studies in neuroscience
Yang Z. et al, (2016), 2016 Conference on Lasers and Electro-Optics, CLEO 2016
A compact light-sheet microscope for the study of the mammalian central nervous system.
Yang Z. et al, (2016), Sci Rep, 6