Rebecca M A Sitsapesan
Emeritus Professor of Pharmacology
I hold a BSc in Pharmacology (Aberdeen), an MSc in Cardiovascular Studies (Leeds) and a PhD in Cardiac Physiology and Pharmacology (Strathclyde). My post-doctoral research into ion-channel biophysics began at the University of Glasgow and continued at the National Heart & Lung Institute at Imperial College, London.
In 1991, I was awarded a British Heart Foundation Basic Science Lectureship to investigate the function of cardiac intracellular Ca2+-release channels and a University Lectureship at Imperial College. I moved to Bristol in 2001 and was promoted to Professor of Pharmacology in 2011. In August 2013, I became Professor of Pharmacology at the University of Oxford.
In June 2019, I retired from the Department of Pharmacology and now hold the position of Emeritus Professor.
Biophysical characteristics of TRIC-A and TRIC-B channels and their regulation of RYR2.
Hu J. et al, (2022), J Gen Physiol, 154
The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca2+ and Mg2.
Wilson AD. et al, (2021), J Physiol
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Bushell SR. et al, (2019), Nat Commun, 10
Quantitative RyR1 reduction and loss of calcium sensitivity of RyR1Q1970fsX16+A4329D cause cores and loss of muscle strength.
Elbaz M. et al, (2019), Hum Mol Genet
Enhanced activity of multiple TRIC-B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents.
O'Brien F. et al, (2019), J Physiol, 597, 2691 - 2705