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Contact information


stephen.mills@pharm.ox.ac.uk


+44 (0)1865 271584

Stephen Mills

BSc (Hons), MPhil, PhD

Postdoctoral Research Chemist

  • Laboratory Manager

First, I prepare new water soluble phosphorylated compounds such as inositol phosphates, benzene phosphates and biphenyl phosphates that mimic or antagonise the action of inositol 1,4,5-trisphosphate (InsP3) or adenophostin and interact with a protein called the Inositol trisphosphate InsP3 receptor (types 1, 2 and 3) that releases Ca2+ ions from its stores. Dysfunction of type 1 Ins(1,4,5)P3 receptor is associated with human diseases of the brain such as Alzheimer's.

Second, I am the laboratory manager for our group and I make sure the lab is supplied with the necessary equipment and chemicals.

I am also interested in the family of enzymes called 5-phosphatases of which there are 10 that degrade InsP3 and higher phosphorylated derivatives such as inositol 1,3,4,5-tetrakisphosphate (InsP4) and 1,3,4,5,6-pentakisphosphate (InsP5) or their phosphorylated lipid derivatives. A number of these enzymes are involved in diabetes, cancer and obesity.  

 

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