Career Development Fellow
Research at the interface of chemistry, biology and drug discovery.
As part of the Medicinal Chemistry Group in the Department of Pharmacology, my research involves the synthesis and development of biologically active small-molecules. This includes identification of new inhibitors by screening approaches, design of improved molecules using rational and computational guidance, and testing of molecules in biochemical, cellular and in vivo settings. Current Medicinal Chemistry projects include: development of molecules to reverse antibiotic resistance; development of inhibitors of the Hedgehog signalling pathway in cancer; identification of modulators of protease activity in cancer and development.
My research in Chemical Biology involves the use of chemical methodology and small molecules to probe biological questions. This encompasses a range of methodology including organic synthesis, biorthogonal 'click' chemistry, and biochemical or mass spectrometry-based proteomic analyses. Current areas of interest include: generation of novel platforms for modulation of protein-protein interactions; profiling of small-molecule targets in vivo.
Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Jamshidiha M. et al, (2022), RSC medicinal chemistry, 13, 150 - 155
Evaluating Hedgehog Acyltransferase Activity and Inhibition Using the Acylation-coupled Lipophilic Induction of Polarization (Acyl-cLIP) Assay.
Andrei SA. et al, (2022), 2374, 13 - 26
Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Coupland CE. et al, (2021), Mol Cell, 81, 5025 - 5038.e10
Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation.
Kallemeijn WW. et al, (2021), Nat Protoc, 16, 5083 - 5122
Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)**
Lanyon‐Hogg T. et al, (2021), Angewandte Chemie, 133, 13654 - 13659