Expeditious functionalization of quinolines in positions 2 and 8 via polyfunctional aryl- and heteroarylmagnesium intermediates
Staubitz A., Dohle W., Knochel P.
An efficient way to prepare functionalized 8-iodo-2-trifluoromethanesulfonyloxyquinolines is presented. The iodo functionality could be selectively converted into other residues via an iodine-magnesium exchange reaction. In addition, the trifluoromethanesulfonate functionality was used as a leaving group in Negishi cross-coupling reactions.