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Research

Our group studies the principles underlying synaptic circuit formation and plasticity. These processes are fundamental to normal brain function, and are implicated in disorders such as epilepsy, schizophrenia and dementia.

Akerman Group

Anthony Group | Experimental Neuropathology

Anthony Group | Experimental Neuropathology

The research in the Adaptive Decisions Lab is focused on understanding the dynamics of micro and mesoscopic circuits, with the primary goal to elucidate how dysfunction in mechanisms at either spatial scale leads to pathophysiology in autism spectrum disorders. We achieve this by combining rodent behavioural tasks with novel mesoscopic and 2-photon calcium imaging, optogenetics, and region-specific CRISPR-Cas9 editing of disease-related genes.

Banerjee group | Adaptive Decisions Lab

We investigate sub-cellular anatomy, especially spatial localisation of organelles, and the role of lysosome mediated calcium signalling in normo- and patho-physiology. Some of the techniques employed in our research include confocal microscopy, electron microscopy, MRI and optogenetics and high-speed optical mapping.

Burton Group | Cardiac Dynamics and Pacemaking Research

We identify and develop small molecules, as either chemical tools to explore basic biology or as drugs to treat disease. We pursue mechanisms controlling calcium signalling and treatments for psychological disorders such as bipolar.

Churchill Group | Chemical Tools and Drugs Discovery

Our research comes under the broad heading of the chemistry of Carbohydrates and Proteins. The reactions and manipulation of sugars and proteins have fascinated organic chemists for over a century and this work is culminating today in a host of new drugs for treating diseases.

Davis Group | Chemistry of Carbohydrates and Protein

We use electrophysiological and live cell imaging techniques to investigate the fundamental mechanisms controlling the diameter of small arteries and arterioles in health and disease.

Dora Group | Vascular Pharmacology Research

We are interested in synaptic transmission. We wish to understand the way in which synapses behave when functioning normally but also how they change during memory formation or when struck by diseases such as Schizophrenia or Alzheimer’s.

Emptage Group | Synaptic Pharmacology

Galione Group | Organellar Ca²⁺ Channels & Signals

Galione Group | Organellar Ca²⁺ Channels & Signals

We use electrophysiological and live cell imaging techniques to investigate the fundamental mechanisms controlling the diameter of small arteries and arterioles in health and disease. These blood vessels regulate tissue blood flow and pressure.

Garland Group | Vascular Pharmacology Research

Our group uses synthetic chemistry and biochemistry to develop small-molecule therapeutics and generate new insights into fundamental biology. We are interested in using tool molecules and interdisciplinary methodology to identify and validate new drug targets and mechanisms of action.

Lanyon-Hogg Group | Medicinal Chemistry & Chemical Biology

Our research mainly seeks to unravel the complexities of cardiac electrical function and its signalling regulation both in physiological and pathological conditions. It will lead to a better mechanistic understanding of hypertrophic and arrhythmic disorders, culminating in the development of more effective therapeutic interventions. We employ cutting-edge techniques encompassing genetic manipulation technologies and multi-scale electrophysiological, optogenetic, and molecular approaches.

Lei Group | Cardiac Signalling Group

We work to find molecular mechanisms that control the activity of nerve cells involved in cognitive processes such as learning and memory, motor behaviour and metabolism.

Minichiello Group | Cellular and Molecular Neuroscience

The group’s principal research interest is in using molecular approaches to study how calcium signalling governs key physiological events.

Parrington Group | Molecular Mechanisms of Cell Signalling

Our interests are in lysosome biology and how diseases result from lysosomal dysfunction. Our research spans basic cell biology, disease mechanism and therapy. We have successfully developed drugs that are in clinical use.

Platt Laboratory | Lysosomal and Sphingolipid Disorders

We design, synthesise and evaluate biologically active molecules and work at the interfaces of Chemistry with Biology and Medicine. Our synthetic tools probe cell signalling and in Medicinal Chemistry our drugs have reached numerous clinical trials, with clinical benefit for cancer patients.

Potter group | Medicinal, Biological Chemistry & Drug Discovery

Our work focuses on understanding the organisation and function of certain neural pathways in the brain that are linked to psychiatric disorder. We are using this knowledge to help identify drugs to improve the treatment of psychiatric disorder.

Sharp Group | Neuropsychopharmacology Research

The release of Ca2+ from intracellular stores is of fundamental importance in cell biology, initiating and regulating a wide variety of cellular functions including muscle contraction, fertilisation, cell division and neurotransmitter release. The focus of our laboratory is the study of intracellularly located ion-channels, particularly in regard to cardiac physiology and disease.

Sitsapesan Group | Intracellular Ion Channels and Ca²⁺ Release

The Group investigates the role of micronutrients, especially B vitamins, in relation to functioning of the brain, in particular in prevention of Alzheimer’s dementia, and in the causation of obesity.

Smith Group | Oxford Project to Investigate Memory and Ageing (OPTIMA) and B Vitamin Research Group

Co-ordinated neuronal activity is intrinsically linked with behaviour and malfunction of neuronal coordination results in psychiatric and neurological disorders. Timing is crucial for neuronal integration including events lasting from milliseconds up to several seconds. Much of the neuronal activity is rhythmic in the brain, as rhythmicity facilitates local and global interactions and enables the representation of temporal sequences.

Somogyi Group

Our research aims are two-fold: i) to determine the molecular mechanisms that underlie the function of vascular ion channels, and ii) to identify new ion channel targets and specific drug compounds with the goal of modulating blood vessel function for therapeutic benefit.

Tammaro Group | Molecular and Systems Pharmacology of Vascular Ion Channels

Chemotherapy can cause heart failure in cancer survivors. We are interested in the mechanism of chemotherapy-induced cardiotoxicity, specifically the role of mitochondrial metabolism in the pathophysiology of ensuing heart failure.

Timm Group | Cardio-oncology and metabolism

We work on drug discovery and target identification for a range of brain-related and metabolic disorders.

Vasudevan Group

Most, if not all, neurodegenerative diseases are defined by the build-up of amyloids - insoluble, fibrous cross-β sheet aggregates of protein. Disorientation is a key early symptom of dementia, but why and how do people become disoriented? The Viney Group investigates the association between amyloids and neural circuit mechanisms underlying spatial orientation in the rodent and human brain. Our main focus of research is on the Papez circuit, a collection of subcortical and cortical brain areas important for spatial navigation, orientation, episodic memory, and cognition. As well as defining cell types of the Papez circuit, we want to understand why specific parts of this circuit accumulate amyloids. Our ultimate goal is to find early biomarkers and develop strategies for slowing down or preventing neurodegenerative diseases such as Alzheimer's disease.

Viney Group | Neuroanatomy & In Vivo Neurophysiology

Research using advanced imaging and electrophysiological techniques to examine the cellular and intracellular mechanisms of the heart and microcirculation

Cardiovascular Pharmacology

Work in the Medicinal Chemistry Group concerns the design, synthesis and biological evaluation of active organic molecules at the interfaces of chemistry and biology

Chemical Biology

Neuropharmacology is the study of the effects of drugs on the nervous system, aiming to develop compounds to benefit humans with psychiatric and neurological disease

Neuropharmacology

Work in the Department includes state of the art subcellular imaging, ion channel electrophysiology (including single channel studies), and the generation of novel molecular and chemical probes to dissect signaling pathways

Signalling

Pharmacology Odyssey M Imaging Facility

Pharmacology Odyssey M Imaging Facility