Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

What's new

Vasudevan lab identifies novel means of improving sensitivity and efficiency for PCR COVID testing

In collaboration with the infectious disease units at the John Radcliffe and Churchill Hospitals, the Vasudevan lab has identified a novel means of improving RT-qPCR sensitivity and efficiency for the detection of SARS-CoV-2 through the concentration of pooled patient lysates.

Sharp group part of €4m EU SEROTONIN and BEYOND project

Inositol hexakisphosphate kinase 1 associates with PI 3-kinase PI3K p85α and generates a local pool of 5-InsP7, which binds the RhoGAP domain of PI3K p85α. 5-InsP7 Binding disinhibits the PI3K p85α interaction with Na⁺/K⁺-ATPase-α1, recruiting AP2 that mediates clathrin-mediated endocytosis leading to downstream degradation of Na⁺/K⁺-ATPase-α1. The structure of 5-InsP7 is illustrated.

International collaboration by Potter group uncovers vital element in regulation of Na⁺/K⁺- ATPase-α1

An international collaboration of the Potter Group with Solomon Snyder’s Group in the USA and with Chinese and German colleagues has uncovered the myo-inositol polyphosphate pyrophosphate 5-InsP7 as a regulator of the Na⁺/K⁺- ATPase-α1

Professor Angela Russell receives 2021 Harrington UK Rare Disease Scholar Award

Angela Russell, Professor of Medicinal Chemistry in the Oxford Departments of Pharmacology and Chemistry, has been announced as one of the five recipients of the inaugural UK Rare Disease Scholar Award, presented by the Harrington Discovery Institute (HDI).

More news