Opportunities

Postdoctoral Neuroscientist

Grade 7: £32,817-£40,322 per annum

We are seeking a postdoctoral neuroscientist to work on a project funded by the Medical Research Council (MRC) that aims to uncover the fundamental mechanisms regulating the integration of newly born neurons into neural circuits during critical periods of brain plasticity underlying cognition, learning and memory. This project builds on the Minichiello group’s recent findings, which show that interfering with specific neural circuits during brain development results in brain disorders that affect later adult life.
 
Therefore, you will use precise genetics with cutting-edge sequencing techniques, including an integrated computational analysis of single-cell transcriptome and epigenome to identify new potential genetic factors regulating time-sensitive periods during brain circuits development. These are fundamental and necessary steps towards the design of innovative pharmacological treatments relevant to neurodevelopmental disorders.
 
You will need to hold a relevant PhD/DPhil, or be close to completing, together with relevant experience in mouse genetic and cutting-edge sequencing techniques, experience in cellular neuroscience, in vivo viral transduction, phenotypic analysis of brain tissues, molecular cell biology relevant to analysis of neuronal phenotypes, and behavioural testing. An ability to manage your own academic research and associated activities and trouble-shoot technical problems is esseential, as is a meticulous approach to practical work and record keeping.
 
The post is available from November 2021 on a fixed-term basis for up to 3 years, funded by the MRC.
 
The closing date for applications is 12 noon on Monday 20 September 2021.

Apply online via the University website

Postdoctoral Research Assistant in Cardiac Ion Function

Grade 7: £32,817-£40,322 per annum

Reporting to Dr Ming Lei, you will be a member of a research group with responsibility for carrying out research on Pnmt derived cardiomyocytes in the heart funded by British Heart Foundation for 3 years. You will take responsibility for maintaining and analysis of mouse models using a wealth of techniques that encompass molecular, biochemical and histological and bioinformatics approaches.
 
You should possess excellent genetic, molecular biological/physiological skills and have substantial experience in the generation and use of transgenic animal models. You will need to manage appropriate genotyping of offspring, be skilled in various electrophysiological techniques and be able to isolate and culture cardiomyocytes both from neonates and adult animals.
 
You will need to hold, or be close to finishing, a relevant PhD/DPhil degree in physiology, cardiovascular biology or pharmacology, together with relevant experience. In addition, you should possess sufficient specialist knowledge in the discipline and the ability to manage your own academic research. Previous experience of contributing to publications/presentations, the ability to contribute ideas for new research projects, and excellent communication skills - including the ability to write for publication, present research proposals and results, and represent the research group at meetings - are also essential.
 
The post is available on a fixed-term basis, for three years, funded by the British Heart Foundation.
 
The closing date for applications is 12noon on Friday 24 September 2021.

Apply via the University website