Limbic Network Synchronization and Temporal Lobe Epilepsy
Jefferys JGR., Jiruska P., de Curtis M., Avoli M.
Abstract Cognitive function, including perception and the formation and recall of memories, depends on the integrated, often synchronous, activity of many neurons. The limbic system in general, and the hippocampal formation in particular, have well-developed anatomical and physiological mechanisms that promote neuronal synchronization. Examples of physiological synchronization include the theta rhythm, beta and gamma oscillations, and sharp-wave ripples. In general, the mechanisms of these synchronous activities depend on intrinsic neuronal properties and the interplay between populations of principal cells and interneurons.