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The effect of two convulsants, benzylpenicillin and pentylenetetrazol, was tested in potential clamp experiments on single rat myelinated nerve fibres. 10 mM concentrations did not affect the permeability properties of the nodal membrane. The convulsive action is therefore probably not mediated through changes in the excitability of central axons.

More information Original publication

DOI

10.1111/j.1748-1716.1980.tb06644.x

Type

Journal article

Publication Date

1980-10-01T00:00:00+00:00

Volume

110

Pages

145 - 148

Total pages

3

Keywords

Animals, Axons, Female, In Vitro Techniques, Membrane Potentials, Nerve Fibers, Myelinated, Penicillin G, Pentylenetetrazole, Rats, Sciatic Nerve