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Mycobacterium tuberculosis Antigen 85 enzymes are vital to the integrity of the highly impermeable cell envelope and are potential therapeutic targets. Kinetic analysis using a label-free assay revealed both mechanistic details and a substrate profile that allowed the design and construction of a selective in vitro mechanism-based inhibitor.

Original publication

DOI

10.1021/ja204249p

Type

Journal article

Journal

J Am Chem Soc

Publication Date

31/08/2011

Volume

133

Pages

13232 - 13235

Keywords

Acyltransferases, Antigens, Bacterial, Antitubercular Agents, Bacterial Proteins, Drug Design, Humans, Models, Molecular, Mycobacterium tuberculosis, Spectrometry, Mass, Electrospray Ionization, Tuberculosis