Figure 4 from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Larkin JR., Anthony S., Johanssen VA., Yeo T., Sealey M., Yates AG., Smith CF., Claridge TDW., Nicholson BD., Moreland J-A., Gleeson F., Sibson NR., Anthony DC., Probert F.
<p><b>A,</b> Fold changes in key metabolites identified by multivariate analysis concentrations in unwell patients with solid tumors relative to the mean metabolite concentrations in unwell patients without cancer. <b>B,</b> Fold changes in key metabolite concentrations in patients with metastatic cancer, relative to the mean metabolite concentration in patients with nonmetastatic cancer. <b>C,</b> Venn diagram illustrating direction of metabolite concentration changes in metastatic and nonmetastatic cancers, relative to unwell patients without cancer. HDL, high-density lipoprotein. Note that “/” represents that the two metabolites overlap in the NMR data, and not a ratio of the two metabolite concentrations. Individual plots of metabolite concentrations are given in Supplementary Fig. S4.</p>