Figure 3 from Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Larkin JR., Anthony S., Johanssen VA., Yeo T., Sealey M., Yates AG., Smith CF., Claridge TDW., Nicholson BD., Moreland J-A., Gleeson F., Sibson NR., Anthony DC., Probert F.
<p><b>A,</b> OPLS-DA plot showing separation of unwell patients with solid tumor diagnoses (blue, filled) from unwell patients with noncancer diagnoses (black, open). <b>B,</b> Sensitivity (dots), specificity (dashes), and F<sub>1</sub> score (continuous) for solid tumors versus unwell patients without cancer (blue), or metastatic versus nonmetastatic cancers (green) at all possible thresholds of classification according to Component 1. Vertical dashed lines show optimal classification threshold for each model. <b>C,</b> ROC curves for classification between unwell with solid tumors versus unwell without cancer diagnoses (blue line; model in <b>A</b>), and metastatic versus nonmetastatic diagnoses (green line; model in <b>C</b>). Small, colored circles on lines indicate points closest to top-left corner, corresponding to dashed vertical lines in <b>B</b>. <b>D,</b> OPLS-DA plot showing separation of patients with nonmetastatic cancer diagnoses (red stars) or metastatic cancer diagnoses (green circles).</p>