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Conjugate addition of lithium amides to (S)-N-acryloyl- or (S)-N-2'-alkylacryloyloxazolidinones and alkylation or protonation of the resulting enolates with 2-pyridone respectively provides a highly stereoselective and product complementary route to a range of (R)- and (S)-2-alkyl-3-aminopropionic acids in good yield and in high ee.

Original publication

DOI

10.1039/b410938d

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

07/12/2004

Pages

2778 - 2779