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Although GABAergic interneurons are the main source of synaptic inhibition in the cortex, activation of GABA(A) receptors has been shown to depolarize specific neuronal compartments, resulting in excitation. By using a noninvasive approach to monitor the effect of individual interneurons on the pyramidal cell population, we found that rat hippocampal interneurons hyperpolarized pyramidal cells irrespective of the location of their synapses along the somato-dendritic axis.

Original publication

DOI

10.1038/nn.2230

Type

Journal article

Journal

Nat Neurosci

Publication Date

01/2009

Volume

12

Pages

21 - 23

Keywords

Action Potentials, Animals, Cell Polarity, Dendrites, Electrophysiology, Hippocampus, Interneurons, Pyramidal Cells, Rats, Receptors, GABA-A, Synaptic Transmission, gamma-Aminobutyric Acid