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Carbohydrates, either bound to proteins or in lipids, play essential roles as communication molecules in many intercellular and intracellular processes. In particular, carbohydrates are important mediators of cell-cell recognition events and have been implicated in related processes such as cell signaling regulation, cellular differentiation and immune response. This diverse utility has long suggested the power of carbohydrates in therapeutic approaches. This Concepts article highlights the recent potential uses of glycoconjugates as therapeutics, with particular reference to glycopeptides, glycoproteins, glycodendrimers, and glycoarrays.

Original publication

DOI

10.1002/chem.200500557

Type

Journal article

Journal

Chemistry

Publication Date

11/01/2006

Volume

12

Pages

656 - 665

Keywords

Animals, Cell Differentiation, Dendrimers, Drug Design, Glycoconjugates, Humans, Signal Transduction