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Complex signal-transduction cascades are known to be involved in regulating cardiomyocyte function, death and survival during acute cardiac ischemia-reperfusion process, but detailed survival signalling pathways are not clear. This review presents and discusses the recent findings bearing upon the evidence on the cardioprotective effect of sphingosine-1-phosphate (S1P) and bradykinin in acute cardiac ischemia-reperfusion and underlying signalling mechanisms, particularly, through activation of P21 activated kinase.

Original publication

DOI

10.1016/j.pbiomolbio.2010.01.001

Type

Journal article

Journal

Prog Biophys Mol Biol

Publication Date

09/2010

Volume

103

Pages

142 - 147

Keywords

Acute Coronary Syndrome, Animals, Bradykinin, Humans, Lysophospholipids, Reperfusion Injury, Signal Transduction, Sphingosine, p21-Activated Kinases