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The synthesis and inhibitory properties towards naringinase (L-rhamnosidase) of L-(+)-swainsonine and of a number of more highly oxygenated analogues, and of some monocyclic equivalents, are reported. L-(+)-swainsonine and 1,4,6-trideoxy-1,4-imino-L-mannitol are powerful and specific inhibitors of naringinase.

Original publication

DOI

10.1016/0040-4039(96)01957-0

Type

Journal article

Journal

Tetrahedron Letters

Publication Date

18/11/1996

Volume

37

Pages

8565 - 8568