Department of Pharmacology

Molecular and biochemical insights into dysregulation of glycosphingolipid metabolism in a mouse model of lysosomal free sialic acid storage disorder.

Sabir MS. et al, (2026), Exp Neurol, 399

Contrasting Effects of Chronic Glucokinase Activation and Inhibition on Pancreatic Beta-Cell Function.

Lloyd M. et al, (2026), FASEB J, 40

Pathological cortico-STN beta coupling in Parkinson's disease is confined to beta bursts

Beaudoin CA. et al, (2026)

2025 consensus clinical management guidelines for Niemann-Pick disease type C

PLATT F., (2026), Journal of Inherited Metabolic Disease

New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels

Martucci L., (2026)

Therapeutic antagonism of a key toxin driving Alzheimer's disease: Comparison of a peptide variant and small molecule.

Cardenal CV. et al, (2026), Biomed Pharmacother, 197

TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition.

Weiden E-M. et al, (2026), EMBO J, 45, 2182 - 2209

Molecular Glue-like Degraders of TEM β-Lactamases by Periplasmic Protease DegP

Taylor EK. et al, (2026)

Rational discovery of therapeutic PAK1 allosteric activators.

He Y. et al, (2026), Cell

Live-cell 3D-SIM of Rift Valley fever virus NSs filaments reveals a polygon web architecture.

Dunlop JI. et al, (2026), Proc Natl Acad Sci U S A, 123

Human iPSC Models of Ganglioside Deficiency Reveal a Sialylated Lipid Requirement for Plasma-Membrane Organization and Neuronal Activity

Barrow HG. et al, (2026)

YdbL directly modulates YdbH-YnbE bridge formation to maintain Escherichia coli outer membrane homeostasis.

De'Ath C. et al, (2026)

The Effect of Neurodegeneration on Ultrasonic Vocalisations (USV) and Their Neuronal Substrates in Mice and Rats: A Systematic Review

Calemi C. et al, (2026)

Layer-Specific Astrocyte Morphological Responses in the CA3 Hippocampus Region During Piry Virus-Induced Encephalitis.

de Almeida Miranda D. et al, (2026), Hippocampus, 36

Links between COVID-19, long COVID, and neurodegeneration: The role of glycosphingolipids.

Spedding M. et al, (2026), Pharmacol Rev, 78

Brain-Directed AAV Gene Therapy Rescues a Mouse Model of the CLN5 Form of Neuronal Ceroid Lipofuscinosis Disease and Normalizes a Blood Plasma Biomarker of Neurodegeneration.

Liu W. et al, (2026), Hum Gene Ther, 37, 241 - 261

Biocompatible ligand balancing in transition metal coordination enables benign in-cell protein arylation.

Fu X. et al, (2026), Nat Chem, 18, 457 - 472

Serum GFAP and NfL augment a metabolomics-driven strategy for long-term prediction of multiple sclerosis progression.

Kacerova T. et al, (2026), Commun Med (Lond), 6

The intracellular inositol (pyro)phosphate receptor AtSPX1 reciprocally binds to P1BS DNA.

Whitfield HL. et al, (2026), Nat Commun, 17

A cardiac pulse signal affects local field potentials recorded from deep brain stimulation electrodes across clinical targets

Tourigny K. et al, (2026)

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