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Minas Salib, in the group led by Tim Viney and Peter Somogyi, has discovered a new type of neuronal pathway that may be important in memory. For the encoding and recall of episodic memories, nerve cells in the cerebral cortex are activated in precisely timed sequences. Rhythmicity facilitates the coordination of neuronal activity and these rhythms are detected as oscillations of different frequencies, such as 5–12 Hz theta oscillations. Degradation of these rhythms, such as through neurodegeneration, causes memory deficits. The medial septum, a part of the basal forebrain that innervates the hippocampal formation, contains neurons that fire with a high degree of rhythmicity (HRNs) and others that fire with a low degree of rhythmicity (LRNs). These distinct types of neuron may contribute differentially to the coordination of cortical neuronal activity. Minas and colleagues discovered that GABAergic LRNs preferentially innervate the dentate gyrus and the CA3 area of the hippocampus, regions important for episodic memory. These neurons act in parallel with the HRNs mostly via transient inhibition of inhibitory neurons. A figure from the paper describing these results was chosen to illustrate the front cover of the 5 June issue of Journal of Neuroscience.
Therapeutic interventions for coronary microvascular obstruction after acute myocardial infarction: Developments and challenges.
Journal article
Maino A. et al, (2026), Pharmacol Ther, 282
The DIPP1 family binds IP8 in catalytically-productive twist-boat and chair conformations and associates in a ligand-dependent manner.
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Casas-Florez D. et al, (2026), Int J Biol Macromol
Discovery of stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction
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De Vita E. et al, (2026)
Emerging therapeutic opportunities for psychedelic and related drugs.
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Wonnacott S. et al, (2026), Br J Pharmacol
SpsB is a target of SOS-response inhibitor OXF-077 and regulates quinolone resistance emergence.
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Bradbury JD. et al, (2026), Cell Chem Biol
Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene-related peptide vasorelaxation in myogenic rat coronary resistance arteries.
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Donovan LA. et al, (2026), Br J Pharmacol
Synthesis of N-Acetyl-D- and -L-Leucine-13C6 Tool Compounds in Neurodegenerative Disease.
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Crepin D. et al, (2026), ChemMedChem, 21
Ultrasound-mediated focal serotonin delivery causally modulates motivation in primates
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Winiarski S. et al, (2026)
Regulation of Ferroptosis Sensitivity in Hepatocellular Carcinoma Cells by Lysosomal Ion Channels TPC2 and TRPML1.
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Geisslinger F. et al, (2026), Antioxidants (Basel), 15
Diversity and sensorimotor specialization of head direction cells in the mouse thalamus
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Hijazi S. et al, (2026), Current Biology
Evaluating the Efficacy of Monoclonal Antibodies Against a Bioactive Peptide Involved in Alzheimer's Disease: A Methodological Approach.
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Bonny G. et al, (2026), Methods Protoc, 9
Calcium-activated chloride channels in pericytes and their role in regulating organ blood flow.
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Tammaro P. and Hashitani H., (2026), J Physiol
Synthesis of aryl-fused bicyclo[3.1.1]heptanes and validation as naphthyl bioisosteres.
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Kerckhoffs A. et al, (2026), Nat Chem
2025 Consensus Clinical Management Guidelines for Niemann-Pick Disease Type C.
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Hiwot T. et al, (2026), J Inherit Metab Dis, 49
Molecular and biochemical insights into dysregulation of glycosphingolipid metabolism in a mouse model of lysosomal free sialic acid storage disorder.
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Sabir MS. et al, (2026), Exp Neurol, 399
No Evidence of Moderated Impulsivity Following Administration of the IMPase Inhibitor Ebselen in Healthy Adults.
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John MPG. et al, (2026), Hum Psychopharmacol, 41
Impaired glucose tolerance and mild diabetes induce β-cell dysfunction in mice.
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Haythorne E. et al, (2026), Nat Commun
Curing the brain: in search for new astrocyte-specific therapies.
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Verkhratsky A. et al, (2026), Exp Mol Med
TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.
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Walth-Hummel AA. et al, (2026), Nat Commun, 17
Structural implications of glycosylation on the voltage-gated sodium channel β3-subunit.
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Beaudoin CA. et al, (2026), J Struct Biol
