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Minas Salib, in the group led by Tim Viney and Peter Somogyi, has discovered a new type of neuronal pathway that may be important in memory. For the encoding and recall of episodic memories, nerve cells in the cerebral cortex are activated in precisely timed sequences. Rhythmicity facilitates the coordination of neuronal activity and these rhythms are detected as oscillations of different frequencies, such as 5–12 Hz theta oscillations. Degradation of these rhythms, such as through neurodegeneration, causes memory deficits. The medial septum, a part of the basal forebrain that innervates the hippocampal formation, contains neurons that fire with a high degree of rhythmicity (HRNs) and others that fire with a low degree of rhythmicity (LRNs). These distinct types of neuron may contribute differentially to the coordination of cortical neuronal activity. Minas and colleagues discovered that GABAergic LRNs preferentially innervate the dentate gyrus and the CA3 area of the hippocampus, regions important for episodic memory. These neurons act in parallel with the HRNs mostly via transient inhibition of inhibitory neurons. A figure from the paper describing these results was chosen to illustrate the front cover of the 5 June issue of Journal of Neuroscience.
Live-cell 3D-SIM of Rift Valley fever virus NSs filaments reveals a polygon web architecture.
Journal article
Dunlop JI. et al, (2026), Proc Natl Acad Sci U S A, 123
Human iPSC Models of Ganglioside Deficiency Reveal a Sialylated Lipid Requirement for Plasma-Membrane Organization and Neuronal Activity
Preprint
Barrow HG. et al, (2026)
YdbL directly modulates YdbH-YnbE bridge formation to maintain Escherichia coli outer membrane homeostasis
Preprint
De'Ath C. et al, (2026)
Therapeutic antagonism of a key toxin driving Alzheimer's disease: Comparison of a peptide variant and small molecule.
Journal article
Cardenal CV. et al, (2026), Biomed Pharmacother, 197
Layer-Specific Astrocyte Morphological Responses in the CA3 Hippocampus Region During Piry Virus-Induced Encephalitis.
Journal article
de Almeida Miranda D. et al, (2026), Hippocampus, 36
Serum GFAP and NfL augment a metabolomics-driven strategy for long-term prediction of multiple sclerosis progression.
Journal article
Kacerova T. et al, (2026), Commun Med (Lond)
The intracellular inositol (pyro)phosphate receptor AtSPX1 reciprocally binds to P1BS DNA.
Journal article
Whitfield HL. et al, (2026), Nat Commun
TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition.
Journal article
Weiden E-M. et al, (2026), EMBO J
A cardiac pulse signal affects local field potentials recorded from deep brain stimulation electrodes across clinical targets
Preprint
Tourigny K. et al, (2026)
Brain-Directed AAV Gene Therapy Rescues a Mouse Model of the CLN5 Form of Neuronal Ceroid Lipofuscinosis Disease and Normalizes a Blood Plasma Biomarker of Neurodegeneration.
Journal article
Liu W. et al, (2026), Hum Gene Ther
Therapeutic interventions for coronary microvascular obstruction after acute myocardial infarction: Developments and challenges.
Journal article
Maino A. et al, (2026), Pharmacol Ther
Miglustat as a Treatment for Adults with Tangier Disease Neuropathy: The MUSTANG N-of-1 Trial with 21 months Clinical Observation.
Journal article
Cook A. et al, (2026), Neurol Ther, 15, 447 - 456
Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials.
Journal article
Griffiths CA. et al, (2026), Nat Biotechnol, 44, 316 - 325
Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence.
Journal article
Vu H. et al, (2026), JHEP Rep, 8
Links between COVID-19, long COVID, and neurodegeneration: The role of glycosphingolipids.
Journal article
Spedding M. et al, (2026), Pharmacol Rev, 78
Near-Infrared Triggered Anion Transport Induces Cancer Cell Death.
Journal article
Ahmad M. et al, (2026), Angew Chem Int Ed Engl, 65
Molecular and biochemical insights into dysregulation of glycosphingolipid metabolism in a mouse model of lysosomal free sialic acid storage disorder.
Journal article
Sabir MS. et al, (2026), Exp Neurol, 399
Integrating NMR Metabolomics and Glycomics for Early Cancer Detection in Patients with Non-Specific Symptoms
Preprint
Kacerova T. et al, (2026)
Proton-selective conductance and gating of the lysosomal cation channel TMEM175.
Journal article
Schulze T. et al, (2026), Proc Natl Acad Sci U S A, 123
