Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Search results (51)

« Back to Publications

Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.

Cogswell TJ. et al, (2024), RSC Med Chem, 15, 3495 - 3506

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's.

Brimblecombe KR. et al, (2024), Eur J Neurosci, 59, 1242 - 1259

Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists.

Wang P. et al, (2024), J Med Chem, 67, 110 - 137

HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms

Kumar P. et al, (2024)

Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.

Luscombe VB. et al, (2023), Eur J Pharmacol, 956

Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.

Josa-Culleré L. et al, (2023), Eur J Med Chem, 258

Screening the Medicines for Malaria Pandemic Response Box chemical library onCaenorhabditis elegansidentifies re-profiled candidate anthelmintic drug leads

Nick M. et al, (2022)

Screening the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads

Nick M. et al, (2022), Frontiers in Tropical Diseases, 3

Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[e][1,4]oxazepin-2(3H)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro.

Josa-Culleré L. et al, (2021), Molecules, 26

Competitive SPR using an intracellular anti-LMO2 antibody identifies novel LMO2-interacting compounds.

Canning P. et al, (2021), J Immunol Methods, 494

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni.

Partridge FA. et al, (2021), ACS Infect Dis, 7, 1260 - 1274

A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2.

Bery N. et al, (2021), Sci Adv, 7

Immunopolymer Lipid Nanoparticles for Delivery of Macromolecules to Antigen-Expressing Cells.

Jain AK. et al, (2020), ACS Appl Bio Mater, 3, 8481 - 8495

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.

Hua P. et al, (2020), Blood, 136, 2410 - 2415

Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.

Quevedo CE. et al, (2020), Bioorg Med Chem, 28

Load More