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Search results (37)

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Endosomal TPC1-mediated Ca2+ nanodomains regulate transferrin receptor trafficking and iron homeostasis.

Burton WJ. et al, (2026), Proc Natl Acad Sci U S A, 123

N-acetyl-L-leucine normalizes Transcription Factor EB activity by stereospecific bidirectional modulation in a HeLa cell model of Niemann-Pick disease type C.

Davis LC. et al, (2026), PLoS One, 21

Stereospecific rapid activation of Transcription Factor EB (TFEB) by Levacetylleucine (NALL)

Davis L. et al, (2025)

N-acetyl-L-leucine (Levacetylleucine) normalizes Transcription Factor EB (TFEB) activity by stereospecific bidirectional modulation

Davis L. et al, (2025)

Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1.

Davis LC. et al, (2023), Cell Calcium, 116

NAADP-Mediated Ca2+ Signalling.

Galione A. et al, (2023), Handb Exp Pharmacol, 278, 3 - 34

Two-pore channels: going with the flows.

Morgan AJ. et al, (2022), Biochem Soc Trans, 50, 1143 - 1155

Acidic Ca2+ stores and immune-cell function.

Davis LC. et al, (2022), Cell Calcium, 101

Choreographing endo-lysosomal Ca2+ throughout the life of a phagosome.

Morgan AJ. et al, (2021), Biochim Biophys Acta Mol Cell Res, 1868

A cellular protection racket: How lysosomal Ca2+ fluxes prevent kidney injury.

Galione A. et al, (2021), Cell Calcium, 93

Defective platelet function in Niemann-Pick disease type C1.

Chen OCW. et al, (2020), JIMD Rep, 56, 46 - 57

NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal Ca2+ nanodomains, calcineurin and dynamin.

Davis LC. et al, (2020), EMBO J, 39

Mechanistic convergence and shared therapeutic targets in Niemann-Pick disease.

Colaco A. et al, (2020), J Inherit Metab Dis, 43, 574 - 585

Revealing the secrets of secretion.

Galione A. and Davis LC., (2018), Elife, 7

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.

Fineran P. et al, (2016), Wellcome Open Res, 1

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