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Search results (35)

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N-acetyl-L-leucine (Levacetylleucine) normalizes Transcription Factor EB (TFEB) activity by stereospecific bidirectional modulation

Davis LC. et al, (2025)

Stereospecific rapid activation of Transcription Factor EB (TFEB) by Levacetylleucine (NALL)

Davis L. et al, (2025)

Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1.

Davis LC. et al, (2023), Cell Calcium, 116

NAADP-Mediated Ca2+ Signalling.

Galione A. et al, (2023), Handb Exp Pharmacol, 278, 3 - 34

Two-pore channels: going with the flows.

Morgan AJ. et al, (2022), Biochem Soc Trans, 50, 1143 - 1155

Acidic Ca2+ stores and immune-cell function.

Davis LC. et al, (2022), Cell Calcium, 101

Choreographing endo-lysosomal Ca2+ throughout the life of a phagosome.

Morgan AJ. et al, (2021), Biochim Biophys Acta Mol Cell Res, 1868

A cellular protection racket: How lysosomal Ca2+ fluxes prevent kidney injury.

Galione A. et al, (2021), Cell Calcium, 93

Defective platelet function in Niemann-Pick disease type C1.

Chen OCW. et al, (2020), JIMD Rep, 56, 46 - 57

NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal Ca2+ nanodomains, calcineurin and dynamin.

Davis LC. et al, (2020), EMBO J, 39

Mechanistic convergence and shared therapeutic targets in Niemann-Pick disease.

Colaco A. et al, (2020), J Inherit Metab Dis, 43, 574 - 585

Revealing the secrets of secretion.

Galione A. and Davis LC., (2018), Elife, 7

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.

Fineran P. et al, (2016), Wellcome Open Res, 1

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.

Ruas M. et al, (2015), EMBO J, 34, 1743 - 1758

TPC: the NAADP discovery channel?

Morgan AJ. et al, (2015), Biochem Soc Trans, 43, 384 - 389

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