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Search results (128)

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N-acetyl-L-leucine (Levacetylleucine) normalizes Transcription Factor EB (TFEB) activity by stereospecific bidirectional modulation

Davis LC. et al, (2025)

Stereospecific rapid activation of Transcription Factor EB (TFEB) by Levacetylleucine (NALL)

Davis L. et al, (2025)

Increased 5-HT2Areceptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelics

Ippolito A. et al, (2024)

Acetylation turns leucine into a drug by membrane transporter switching.

Churchill GC. et al, (2021), Sci Rep, 11

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.

Jagannath A. et al, (2021), Nat Commun, 12

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance.

Churchill GC. et al, (2020), PLoS One, 15

A master protocol to investigate a novel therapy acetyl-L-leucine for three ultra-rare neurodegenerative diseases: Niemann-Pick type C, the GM2 Gangliosidoses, and Ataxia Telangiectasia

Fields T. et al, (2020)

Acetylation of L-leucine switches its carrier from the L-amino acid transporter (LAT) to organic anion transporters (OAT)

Churchill G. et al, (2020)

Plasma glutathione suggests oxidative stress is equally present in early- and late-onset bipolar disorder.

Singh N. et al, (2019), Bipolar Disord, 21, 61 - 67

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance

Churchill G. et al, (2019)

The putative lithium-mimetic ebselen reduces impulsivity in rodent models.

Barkus C. et al, (2018), J Psychopharmacol, 32, 1018 - 1026

Ebselen has lithium-like effects on central 5-HT2A receptor function.

Antoniadou I. et al, (2018), Br J Pharmacol, 175, 2599 - 2610

Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.

Fernández B. et al, (2016), Autophagy, 12, 1487 - 1506

Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.

Masaki C. et al, (2016), Psychopharmacology (Berl), 233, 2655 - 2661

Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans.

Singh N. et al, (2016), Neuropsychopharmacology, 41, 1768 - 1778

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