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Search results (17)

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Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR.

Kühn FJP. et al, (2019), Sci Rep, 9

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease.

Zhang B. et al, (2018), Sci Rep, 8

Direct Activation of NADPH Oxidase 2 by 2-Deoxyribose-1-Phosphate Triggers Nuclear Factor Kappa B-Dependent Angiogenesis.

Vara D. et al, (2018), Antioxid Redox Signal, 28, 110 - 130

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose".

Watt JM. et al, (2017), Sci Rep, 7

2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.

Fliegert R. et al, (2017), Nat Chem Biol, 13, 1036 - 1044

Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy.

Kyratsous NI. et al, (2017), Proc Natl Acad Sci U S A, 114, E6381 - E6389

Context-dependent calcium signaling in encephalitogenic T cells – an in vivo two-photon imaging study

Potter BVL. and Watt JM., (2017), Proceedings of the National Academy of Sciences of USA

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.

Fliegert R. et al, (2017), Biochem J, 474, 2159 - 2175

Designer small molecules to target calcium signalling.

Swarbrick JM. et al, (2015), Biochem Soc Trans, 43, 417 - 425

Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.

Swarbrick JM. et al, (2014), J Med Chem, 57, 8517 - 8529

'Click cyclic ADP-ribose': a neutral second messenger mimic.

Swarbrick JM. et al, (2014), Chem Commun (Camb), 50, 2458 - 2461

Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists.

Moreau C. et al, (2013), J Med Chem, 56, 10079 - 10102

Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation.

Nebel M. et al, (2013), J Biol Chem, 288, 16017 - 16030

CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template.

Moreau C. et al, (2013), PLoS One, 8

Total synthesis of a cyclic adenosine 5'-diphosphate ribose receptor agonist.

Swarbrick JM. and Potter BVL., (2012), J Org Chem, 77, 4191 - 4197

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