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Search results (58)

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TPC1-dependent control of endosomal pH and transferrin uptake determines cellular iron status.

Deutsch R. et al, (2026), Proc Natl Acad Sci U S A, 123

Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation.

Mu Q. et al, (2026), EMBO J

Regulation of Ferroptosis Sensitivity in Hepatocellular Carcinoma Cells by Lysosomal Ion Channels TPC2 and TRPML1.

Geisslinger F. et al, (2026), Antioxidants (Basel), 15

TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition.

Weiden E-M. et al, (2026), EMBO J, 45, 2182 - 2209

Proton-selective conductance and gating of the lysosomal cation channel TMEM175.

Schulze T. et al, (2026), Proc Natl Acad Sci U S A, 123

Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors.

Calvo B. et al, (2025), J Cell Biol, 224

Physiological functions and pharmacological targeting of transient receptor potential channels.

Chubanov V. et al, (2025), Pharmacol Rev, 77

TRPML2 channel modulation by PI(3,5)P₂ and small-molecule agonists controls endosomal vesicle dynamics.

Gu Z-Q. et al, (2025), Biomed Pharmacother, 189

TPCs: FROM PLANT TO HUMAN.

Klingl YE. et al, (2025), Physiol Rev, 105, 1695 - 1732

TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family.

Schmiege P. et al, (2025), Nat Commun, 16

Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux.

Chen R. et al, (2025), Nat Commun, 16

Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease.

Gregori M. et al, (2025), J Cell Biol, 224

Unraveling pH Regulation of TMEM175, an Endolysosomal Cation Channel With a Role in Parkinson's Disease.

Schulze T. et al, (2025), J Cell Physiol, 240

TPC2: From Blond Hair to Melanoma?

Abrahamian C. et al, (2024), Cancers (Basel), 16

Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis.

Abrahamian C. et al, (2024), Nat Commun, 15

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