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A collaboration between the Russell group (Chemistry and Pharmacology) and the Davies group (Physiology, Anatomy and Genetics) has identified, via a chemical proteomics and phenotypic profiling strategy, the arylhydrocarbon receptor (AhR) as the molecular target of ezutromid, the utrophin modulator that recently completed a Phase 2 clinical trial in Duchenne muscular dystrophy patients.
Cardiovascular Pharmacology
Research using advanced imaging and electrophysiological techniques to examine the cellular and intracellular mechanisms of the heart and microcirculation
Medicinal Chemistry
Work in the Medicinal Chemistry Group concerns the design, synthesis and biological evaluation of active organic molecules at the interfaces of chemistry and biology
Neuropharmacology
Neuropharmacology is the study of the effects of drugs on the nervous system, aiming to develop compounds to benefit humans with psychiatric and neurological disease
Signalling
Work in the Department includes state of the art subcellular imaging, ion channel electrophysiology (including single channel studies), and the generation of novel molecular and chemical probes to dissect signaling pathways