Search results
Found 117 matches for
The Galione Lab has a paper published in The EMBO Journal showing that local Ca2+‐nanodomains formed by two‐pore channels (TPCs) on endo-lysosomes are shown to drive phagocytosis in macrophages. Moreover, different endo-lysosomal Ca2+ channels do different jobs at phagocytosis (extreme compartmentation).
Akerman group paper wins inaugural Sejnowski-Hinton Prize
4 December 2025
Congratulations to Professor Colin Akerman and members of his team who have been awarded the inaugural Sejnowski-Hinton Prize for their groundbreaking 2016 paper “Random synaptic feedback weights support error backpropagation for deep learning”
New paper from the Viney group explores mechanisms of spatial disorientation
25 November 2025
A new paper, entitled “Pathological tau alters head direction signaling and induces spatial disorientation”, has recently been published by the Viney group.
Behind the photographs: Shared pre-war histories of the British and German Pharmacological Societies
14 October 2025
On Friday 3rd October the Department of Pharmacology hosted a unique event supported by the British and German Pharmacological Societies to explore their shared histories pre-war and the subsequent disruption of academic careers.
BHF Non-clinical PhD Studentship - apply now
3 October 2025
A three-year PhD studentship, funded by the British Heart Foundation, is available in the cardiac signalling group of Professor Ming Lei.
New bifunctional, bispecific nanobodies scaffold helps with small protein imaging
19 August 2025
Researchers at the Rosalind Franklin Institute, the Oxford Department of Pharmacology, and Diamond Light Source have combined their expertise to create new scaffolding molecules to allow the electron microscopy imaging of small proteins (below 50 kDa). Using this method the team have solved the smallest protein structure to date by cryoEM, that of hen egg white lysozyme, which is just 14 kDa.
Christian Grimm awarded title of Professor
24 July 2025
Christian Grimm in the Department of Pharmacology has been awarded the title of Professor by the University's Senior Appointments Panel.
Ming Lei awarded 2026 Mabel Fitzgerald Prize for Diversity in Physiology
4 June 2025
Congraulations to Professor Ming Lei who has been announced as the recipient of the 2026 Mabel Fitzgerald Prize for Diversity in Physiology, presented by the Physiological Society.
Modernized Oxford anti-arrhythmic drug classification gains global recognition as the new standard in antiarrhythmic drug clinical guidelines
12 May 2025
Cardiac arrhythmias pose a serious global health challenge. The commonest sustained arrhythmia atrial fibrillation (AF) affects 1–2% of the worldwide population. Antiarrhythmic drugs (AADs) remain central to their pharmacotherapeutic management. As a solution, Professors Ming Lei, Derek Terrar (both Pharmacology), Christopher Huang (University of Cambridge), and Lin Wu (Beijing University Hospital) developed and proposed the 2018 Oxford modernized antiarrhythmic drug (AAD) classification (Circulation, 2018;138:1879–1896).
New Akerman group paper reveals links between sleep, synaptic inhibition, and the plastic changes that underlie learning in the brain
25 February 2025
Pharmacology researchers have discovered a key mechanism linking sleep and wake to synaptic plasticity in the brain, shedding light on how learning and memory may be affected by rest. Their study, published by Alfonsa et al. in the journal Current Biology, reveals that intracellular chloride levels shift during sleep and wakefulness, influencing synaptic plasticity processes in the brain’s cortex.
Professor Ben Davis awarded 2025 Claude S Hudson Award
12 February 2025
Congratulations to Professor Ben Davis who has been announced as the recipient of the 2025 Claude S Hudson Award, presented by the American Chemical Society (ACS).
Anthony group research offers new treatment hope for ALS patients
9 December 2024
New research, led by the Anthony Group in Pharmacology and funded by GeNeuro, suggests a pathway to a new precision medicine approach for patients with amyotrophic lateral sclerosis (ALS). The groundbreaking findings were presented at the 35th International Symposium on ALS/MND, which took place in Montreal, Canada, from 6-8 December 2024.
Parrington group paper reveals role for TPC1 channels in mTORC1 activity
13 November 2024
New research published by the Parrington group help further understand the link between mTORC1 and endolysosomal ion channels, and reveal that TPC1 controls melanoma progression and represents a potential therapeutic target.
Discovery of key mechanism in Huntington’s Disease could pave the way for early detection and treatment
6 November 2024
New research published by the Minichiello group in Nature Metabolism has identified a key biochemical mechanism relevant to Huntington’s Disease, which opens the possibility of studying the disease before its clinical onset.
Batteries for miniature bio-integrated devices and robotics — here’s how to do it
4 November 2024
A new paper, published this week in Nature Chemical Engineering, highlights ground-breaking collaborative research between the Departments of Chemisty and Pharmacology to develop batteries for miniature bio-integrated devices. Featuring work carried out in the Lei Group, the research has led to the creation of a flexible soft lithim-ion battery constructed by assembling biocompatible hydrogel droplets.
Akerman group study describes first new all-optical tool for quantifying inhibitory receptor driving forces
28 October 2024
A new paper from the Akerman group, published in the journal Nature Communications this week, explains the development of a new ‘ORCHID’ biosensor to measure the driving force acting on inhibitory receptors in the brain.
Minichiello group shows neurotrophin signalling dysfunction in a subset of cerebellar granule cells triggers ataxia
22 October 2024
A new study from the Minichiello group, published recently in the journal Biology, has shown that dysfunction in BDNF-TrkB signalling, restricted to a specific subset of cerebellar granule cells, is sufficient to generate ataxic symptoms
Department of Pharmacology research leads to FDA approval for new NPC treatment
26 September 2024
A Department of Pharmacology start-up company has received approval from the US Food and Drug Administration (FDA) for a new treatment for the rare lysosomal storage disorder Niemann-Pick Disease Type C (NPC) in both adults and children.
Collaboration in action - from a Pharmacology perspective
21 June 2024
As part of the Medical Sciences Division's series on industry collaboration, Pharmacology's Associate Professor Sri Vasudevan shares the important of networking at conferences and listening to a range of views as vital building blocks that can lead to effective commercial partnerships.
Pharmacology scientist awarded Royal Society of Chemistry prize
12 June 2024
Professor Angela Russell, who holds a joint appiontment with the Departments of Pharmacology and Chemistry, is one of four scientists from the University of Oxford who have won prizes from the Royal Society of Chemistry in recognition of brilliance in research and innovation. The awards are among the oldest and most prestigious research prizes in the world, having recognised excellence in the chemical sciences for more than 150 years.