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The Galione Lab has a paper published in The EMBO Journal showing that local Ca2+‐nanodomains formed by two‐pore channels (TPCs) on endo-lysosomes are shown to drive phagocytosis in macrophages. Moreover, different endo-lysosomal Ca2+ channels do different jobs at phagocytosis (extreme compartmentation).
Professor Angela Russell receives 2021 Harrington UK Rare Disease Scholar Award
Department Russell Group
15 October 2020
Angela Russell, Professor of Medicinal Chemistry in the Oxford Departments of Pharmacology and Chemistry, has been announced as one of the five recipients of the inaugural UK Rare Disease Scholar Award, presented by the Harrington Discovery Institute (HDI).
Russell group research reveals molecular target of the Utrophin modulator Ezutromid
Department Russell Group
6 January 2020
A collaboration between the Russell group (Chemistry and Pharmacology) and the Davies group (Physiology, Anatomy and Genetics) has identified, via a chemical proteomics and phenotypic profiling strategy, the arylhydrocarbon receptor (AhR) as the molecular target of ezutromid, the utrophin modulator that recently completed a Phase 2 clinical trial in Duchenne muscular dystrophy patients.
Nature Comms paper highlights a new strategy for targeting protein-protein interactions (PPIs) for the development of new small molecule therapeutics
Department Russell Group
25 September 2018