TPC2 in drug development: Emerging target for cancer, viral infections, cardiovascular diseases, and neurological disorders.
Alharbi AF. and Parrington J., (2025), Pharmacol Res, 213
Whole-exome sequencing identifies cancer-associated variants of the endo-lysosomal ion transport channels in the Saudi population
Binobaid L. et al, (2024), Saudi Pharmaceutical Journal, 32
TPC2 targeting evolution: Leveraging therapeutic opportunities for cancer.
Alharbi AF. and Parrington J., (2021), Cell Chem Biol, 28, 1103 - 1105
The role of genetic polymorphisms in endolysosomal ion channels TPC2 and P2RX4 in cancer pathogenesis, prognosis, and diagnosis: a genetic association in the UK Biobank.
Alharbi AF. and Parrington J., (2021), NPJ Genom Med, 6
Targeting Two-Pore Channels: Current Progress and Future Challenges.
Jin X. et al, (2020), Trends Pharmacol Sci, 41, 582 - 594
The eggstraordinary story of how life begins.
Parrington J. et al, (2019), Mol Reprod Dev, 86, 4 - 19
Generation of TPC2 knock out pig embryos by CRISPR-Cas technology
Gadea J. et al, (2018), REPRODUCTION IN DOMESTIC ANIMALS, 53, 87 - 88
Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain.
He H. et al, (2018), Physiol Genomics, 50, 605 - 614
PLC zeta is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence
Hachem A. et al, (2018), GENETICS RESEARCH, 100
Mutations in the sperm-activating factor PLCZ1 causing fertilization failure after ICSI lead to partial hydatidiform moles
Guggilla RR. et al, (2018), HUMAN REPRODUCTION, 33, 356 - 357
PLCz knock-out sperm reveals the sole effect of altering calcium signals during assisted oocyte activation on later mouse embryogenesis
Buitrago MF. et al, (2018), HUMAN REPRODUCTION, 33, 27 - 27
PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence.
Hachem A. et al, (2017), Development, 144, 2914 - 2924
Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling.
Lin WK. et al, (2017), J Biol Chem, 292, 13243 - 13257
Sperm-specific Phospholipase-C-isoform zeta (PLC zeta) is the physiological trigger of calcium oscillation in mammalian eggs
Hachem A. et al, (2017), HUMAN REPRODUCTION, 32, 188 - 189
Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos.
Kelu JJ. et al, (2017), Dev Biol, 425, 109 - 129
Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.
Garcia-Rua V. et al, (2016), J Biosci, 41, 643 - 658
Metabolic alterations derived from the absence of Two-Pore Channel 1 (TPCN1) at cardiac level
Feijoo-Bandin S. et al, (2016), EUROPEAN HEART JOURNAL, 37, 306 - 306