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Contact information

Email
carole.bataille@pharm.ox.ac.uk

Carole Bataille

Postdoctoral Research Assistant in Medicinal Chemistry

Key publications

A Biased Agonist at Immunometabolic Receptor GPR84 Causes Distinct Functional Effects in Macrophages.

Lucy D. et al, (2019), ACS Chem Biol, 14, 2055 - 2064

Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.

Cruz-Migoni A. et al, (2019), Proc Natl Acad Sci U S A, 116, 2545 - 2550

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.

Bery N. et al, (2018), Elife, 7

Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.

Bataille CJR. et al, (2017), Bioorg Med Chem, 25, 2657 - 2665

Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo.

Partridge FA. et al, (2017), PLoS Negl Trop Dis, 11

Hydrogen-bonding-mediated directed osmium dihydroxylation

Donohoe TJ. et al, (2011), Organic Reactions, 76, 1 - 48

Recent publications

Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.

Cogswell TJ. et al, (2024), RSC Med Chem, 15, 3495 - 3506

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's.

Brimblecombe KR. et al, (2024), Eur J Neurosci, 59, 1242 - 1259

Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists.

Wang P. et al, (2024), J Med Chem, 67, 110 - 137

HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms

Kumar P. et al, (2024)

Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.

Josa-Culleré L. et al, (2023), Eur J Med Chem, 258

Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.

Luscombe VB. et al, (2023), Eur J Pharmacol, 956

Screening the Medicines for Malaria Pandemic Response Box chemical library onCaenorhabditis elegansidentifies re-profiled candidate anthelmintic drug leads

Nick M. et al, (2022)

Screening the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads

Nick M. et al, (2022), Frontiers in Tropical Diseases, 3

More publications