Contact information
Research groups
Colleges
Lora L. Martucci
BSc, MSc, PhD
Junior Research Fellow, New College
- Postdoctoral Fellow, Department of Pharmacology
Deciphering the role of TPCs in neuropeptide secretion
Biography
I obtained my PhD in 2021 from Paris Saclay University in France. During my years as a PhD student, I discovered that the TPCs (Two-Pore Channels) were involved in the secretion of the neurohormone oxytocin. A deletion of TPCs in mice result in very low oxytocin plasma levels along with altered social behaviour.
In 2021 I obtain a fellowship from the New College and I am now studying the signalling pathway of TPCs in neuropeptide release and deciphering the mechanisms underlying TPC involvement in oxytocin secretion.
Websites
Recent publications
New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
Thesis / Dissertation
Martucci L., (2026)
Low Temperature Delays the Effects of Ischemia in Bergmann Glia and in Cerebellar Tissue Swelling.
Journal article
Li X. et al, (2023), Biomedicines, 11
Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion.
Journal article
Martucci LL. et al, (2023), Proc Natl Acad Sci U S A, 120
NAADP-Mediated Ca2+ Signalling.
Journal article
Galione A. et al, (2023), Handb Exp Pharmacol, 278, 3 - 34
Two-pore channels: going with the flows.
Journal article
Morgan AJ. et al, (2022), Biochem Soc Trans, 50, 1143 - 1155