Christian Grimm
Professor of Organelle Biology and Pharmacology
Dr Christian Grimm joined the Department from 1 April on a 50% FTE appointment. Christian will retain a 50% post in the Walther Straub Institute of Pharmacology and Toxicology at Ludwig-Maximilians-Universität (LMU) in Munich.
Since completing his PhD at the University Berlin in 2004, Christian has postdocotral research experience at both Harvard and Stanford Universities in the US along with industrial experience with Bayer and Pfizer.
His research is focussed on intracellular/endolysosomal ion channels as novel targets for disease therapy (in particular ion channels in lysosomes and endosomes), with several ongoing established industry collaborations. Of particular interest is the physiology and pathophysiology of several diseases associated with lysosomal dysfunction such as metabolic and neurodegenerative diseases/ lysosomal storage disorders.
Christian will lead on the development of Pharmacology’s Centre for Organelle Drug Discovery (CODD).
Key publications
A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.
Journal article
Villella VR. et al, (2019), EMBO J, 38
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.
Journal article
Chen C-C. et al, (2014), Nat Commun, 5
A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse.
Journal article
Grimm C. et al, (2007), Proc Natl Acad Sci U S A, 104, 19583 - 19588