In collaboration with colleagues at the University of Nottingham, the Burton group in Pharmacology performed safety modelling with uncertainty quantification using a risk classifier based on the qNet torsade metric score, a measure of the net charge carried by major currents during the action potential under inhibition of multiple ion channels by a compound. Our simulation approach highlights that the torsadogenic potentials of hydorxychloqoruine (HCQ), chloroquine (CQ) and other QT-prolonging anti-infectives used in COVID-19 prevention and treatment increase with concentration and in combination with other QT-prolonging drugs.
Burton group paper models cardiac arrrhythmia risk of anti-infective compounds including chloroquine and hydroychloroquine
13 April 2021