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In collaboration with colleagues at the University of Nottingham, the Burton group in Pharmacology performed safety modelling with uncertainty quantification using a risk classifier based on the qNet torsade metric score, a measure of the net charge carried by major currents during the action potential under inhibition of multiple ion channels by a compound. Our simulation approach highlights that the torsadogenic potentials of hydorxychloqoruine (HCQ), chloroquine (CQ) and other QT-prolonging anti-infectives used in COVID-19 prevention and treatment increase with concentration and in combination with other QT-prolonging drugs.

https://royalsocietypublishing.org/doi/10.1098/rsos.210235

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