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In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their unique distribution in the heart, electrical activity, Ca2+ transient properties, and potential role in localized adrenergic signaling are discussed.

Original publication

DOI

10.3389/fphys.2019.00713

Type

Journal article

Journal

Front Physiol

Publication Date

2019

Volume

10

Keywords

Pnmt, Pnmt-derived cardiomyocytes, catecholamines, heart, optogenetics