Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives.
Fan X., Sun T., Crawford W., Tan X., Ou X., Terrar DA., Ebert SN., Lei M.
In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their unique distribution in the heart, electrical activity, Ca2+ transient properties, and potential role in localized adrenergic signaling are discussed.