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This Perspective by Galione and Churchill is one in a series on intracellular calcium release mechanisms. The authors review the evidence for cyclic adenosine diphosphate ribose (cADPR) being a second messenger involved in regulating intracellular calcium. In addition, the physiological stimuli and responses mediated by cADPR are discussed. The Perspective is accompanied by a movie showing a calcium wave triggered by cADPR.

Original publication

DOI

10.1126/stke.2000.41.pe1

Type

Journal article

Journal

Sci STKE

Publication Date

18/07/2000

Volume

2000

Keywords

Adenosine Diphosphate Ribose, Animals, Calcium, Calcium Signaling, Cyclic ADP-Ribose, Humans, Second Messenger Systems