A role for the cortex in sleep-wake regulation
Krone L., Yamagata T., Blanco-Duque C., Guillaumin M., Kahn M., Akerman C., Hoerder-Suabedissen A., Molnár Z., Vyazovskiy V.
Abstract The cortex and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global control of vigilance states. Here we silenced a subset of cortical layer 5 pyramidal and dentate gyrus granule cells in mice using a cell-specific ablation of the key t-SNARE protein SNAP25. We found a marked increase in wakefulness accompanied by a reduced rebound of EEG slow-wave activity after sleep deprivation. Our data illustrates an important role for the cortex in both global state control and sleep homeostasis.