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Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.

Original publication




Journal article


Chem Commun (Camb)

Publication Date





5182 - 5185


Anticarcinogenic Agents/chemistry/*pharmacology Breast Neoplasms/*drug therapy/pathology Cell Line, Tumor Cell Proliferation/drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Female Humans Isothiocyanates/chemistry/*pharmacology MCF-7 Cells Molecular Structure *Proteomics Structure-Activity Relationship