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Since the identification of the membrane-bound O-acyltransferase (MBOATs) protein family in the early 2000s, three distinct members [porcupine (PORCN), hedgehog (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (GOAT)] have been shown to acylate specific proteins or peptides. In this review, topology determination, development of assays to measure enzymatic activities and discovery of small molecule inhibitors are compared and discussed for each of these enzymes.

Original publication

DOI

10.1042/BST20150018

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

2015

Volume

43

Pages

246 - 252

Keywords

Acylation/genetics Acyltransferases/antagonists & inhibitors/genetics/*metabolism Animals Cell Membrane/enzymology/metabolism Ghrelin/antagonists & inhibitors/genetics/*metabolism Humans Lipoylation/genetics Membrane Proteins/antagonists & inhibitors/genetics/*metabolism Small Molecule Libraries/pharmacology