Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.

Original publication

DOI

10.1016/j.bmcl.2010.12.099

Type

Journal article

Journal

Bioorg Med Chem Lett

Publication Date

15/02/2011

Volume

21

Pages

1185 - 1190

Keywords

Amino Alcohols, Antitubercular Agents, Arylamine N-Acetyltransferase, Binding Sites, Catalytic Domain, Computer Simulation, Mycobacterium, Structure-Activity Relationship