Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVE: To determine whether individuals with Alzheimer's disease (AD) and the K variant allele of butyrylcholinesterase have a slower rate of cognitive decline than those without the K variant allele of butyrylcholinesterase. METHOD: The cognitive status of 339 community based subjects with AD was assessed with the Mini Mental State Examination at baseline and yearly over a three year follow up period. The rates of cognitive decline of subjects with and without the K variant allele were compared. RESULT: Presence of the K allele was associated with a slower average rate of cognitive decline in subjects with severe AD. CONCLUSIONS: This finding is consistent with the suggestion that the K variant of butyrylcholinesterase has an important role in disease progression in AD, and this may have implications for treatment.

Original publication

DOI

10.1136/jnnp.2004.039321

Type

Journal article

Journal

J Neurol Neurosurg Psychiatry

Publication Date

05/2005

Volume

76

Pages

640 - 643

Keywords

Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Butyrylcholinesterase, Cognition Disorders, Cohort Studies, Demography, Female, Genetic Variation, Genotype, Humans, Male, Neuropsychological Tests