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Propagating Ca2+ waves are a characteristic feature of Ca(2+)-linked signal transduction pathways. Intracellular Ca2+ waves are formed by regenerative stimulation of Ca2+ release from intracellular stores by Ca2+ itself. Mechanisms that rely on either inositol trisphosphate or ryanodine receptor channels have been proposed to account for Ca2+ waves in various cell types. Both channel types contributed to the Ca2+ wave during fertilization of sea urchin eggs. Alternative mechanisms of Ca2+ release imply redundancy but may also allow for modulation and diversity in the generation of Ca2+ waves.

Original publication

DOI

10.1126/science.8392748

Type

Journal article

Journal

Science

Publication Date

16/07/1993

Volume

261

Pages

348 - 352

Keywords

Adenosine Diphosphate Ribose, Adenosine Triphosphate, Animals, Caffeine, Calcium, Calcium Channels, Cyclic ADP-Ribose, Female, Fertilization, Heparin, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Muscle Proteins, Ovum, Receptors, Cell Surface, Receptors, Cytoplasmic and Nuclear, Ryanodine, Ryanodine Receptor Calcium Release Channel, Sea Urchins, Signal Transduction, Thimerosal, Xenopus