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A strategy for the site-specific attachment of 2-deoxy-2-fluorosugars to cysteine and dehydroalanine tagged proteins is reported. When combined with thionation of fluorosugars, such as the widely available (18)F probe 2-deoxy-2-[(18)F]fluoroglucose ([(18)F]FDG), this methodology allows fast and direct access to site-specific [(18)F]FDG-labelled proteins.

Original publication

DOI

10.1039/c1cc13524d

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

28/09/2011

Volume

47

Pages

10010 - 10012

Keywords

Cysteine, Fluorodeoxyglucose F18, Isotope Labeling, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Positron-Emission Tomography, Proteins, Radiopharmaceuticals, Subtilisin