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Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is "anti-Hebbian":Itis induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity.

Original publication

DOI

10.1126/science.1137450

Type

Journal article

Journal

Science

Publication Date

02/03/2007

Volume

315

Pages

1262 - 1266

Keywords

Animals, Electric Stimulation, Excitatory Postsynaptic Potentials, Hippocampus, Interneurons, Long-Term Potentiation, Male, Membrane Potentials, Neural Inhibition, Patch-Clamp Techniques, Pyramidal Cells, Rats, Rats, Sprague-Dawley, Receptors, AMPA, Receptors, N-Methyl-D-Aspartate, Spermine, Synapses