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Benign C-C bond formation at various sites in cell-surface channels has been achieved through Suzuki-Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of Escherichia coli ; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms.

Original publication

DOI

10.1021/ja209352s

Type

Journal article

Journal

J Am Chem Soc

Publication Date

18/01/2012

Volume

134

Pages

800 - 803

Keywords

Boronic Acids, Catalysis, Escherichia coli, Escherichia coli Proteins, Membrane Proteins, Models, Molecular, Molecular Structure, Palladium, Protein Conformation