Enabling olefin metathesis on proteins: chemical methods for installation of S-allyl cysteine.

Chalker JM.; Lin YA.; Boutureira O.; Davis BG.

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Enabling olefin metathesis on proteins: chemical methods for installation of S-allyl cysteine.

Chalker JM., Lin YA., Boutureira O., Davis BG.

Multiple, complementary methods are reported for the chemical conversion of cysteine to S-allyl cysteine on protein surfaces, a useful transformation for the exploration of olefin metathesis on proteins.

Original publication

DOI

10.1039/b908004j

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

07/07/2009

Pages

3714 - 3716

Keywords

Alkenes, Allyl Compounds, Bacillus, Cysteine, Models, Molecular, Protein Conformation, Proteins, Substrate Specificity, Subtilisin, Sulfides