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An experimentally simple protocol for the very highly (E)-selective Wadsworth-Emmons reaction [(E):(Z) selectivities in excess of 180:1 in some cases] of a range of straight-chain and branched aliphatic, substituted aromatic, and base-sensitive aldehydes via reaction with an alkyl diethylphosphonoacetate and MeMgBr is reported.

Original publication

DOI

10.1021/ol802212e

Type

Journal article

Journal

Org Lett

Publication Date

04/12/2008

Volume

10

Pages

5437 - 5440