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Given the dependence of much modern biology upon the use of antibodies as tools and reagents, their variability and the often associated lack-of-detail about function and identity creates experimental errors. Here we describe the proof-of-principle for a potentially general, versatile method for the display of antigens in a soluble yet standard format on a lateral protein scaffold that mimics normal epitopes in a protein antigen (a 'mimogen') and confirm their utility in phosphorylation-dependent recognition by specific antibodies.

Original publication

DOI

10.1039/c5cc08892e

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

18/02/2016

Volume

52

Pages

3014 - 3017

Keywords

Antigens, Peptides