Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A mild route to indoles by cyclization of 2-(1-alkynyl)anilines is offered by the use of simple bases such as KOtBu, KH, or CsOtBu and N-methylpyrrolidinone (NMP) at room temperature. The reaction has a broad scope and allows the preparation of various functionalized indoles as well as new aza-or diazaindoles in excellent yields [see, for example, Eq. (1)].

Original publication

DOI

10.1002/1521-3773(20000717)39:14<2488::AID-ANIE2488>3.0.CO;2-E

Type

Journal article

Journal

Angewandte Chemie - International Edition

Publication Date

17/07/2000

Volume

39

Pages

2488 - 2490