Synthetic modulators of the polyphosphoinositide pathway of signal transduction
Potter BVL., Riley AM., Mills SJ., Jenkins DJ., Changsheng L., Lampe D.
Syntheses of regiochemically and structurally modified analogues of D-myo-inositol 1,4,5-trisphosphate are described to give second messenger mimics, enzyme inhibitors and receptor antagonists, demonstrating new leads for the design of agents to interfere with a key pathway of signal transduction.