Bicyclic analogues of inositol 1,4,5-trisphosphate based upon adenophostin A
Riley AM., Potter BVL.
The synthesis from myo-inositol of two bicyclic fused ring analogues of 1D-myo-inositol 1,4,5-trisphosphate in optically active form is described. The route demonstrates the application of the recently described butane-2,3- diacetal (BDA) protecting group to inositol chemistry, and features a novel construction of a dioxabicyclo[5.4.0]system using 3-chloro-2-chloromethyl-1- propene.